Can elevated liver enzymes cause itching?

15 Elevated Liver Enzymes - Causes Signs and Symptom

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  1. Pruritus can develop at any stage of cholestatic liver disease and it should be particularly noted that severity of cholestatic itch is independent of the duration, biochemical severity, and histological stage of the underlying liver disease
  2. Celiac disease can cause elevated liver enzymes and the rash you describe sounds like dermatitis herpetiformis. Both are autoimmune diseases that are managed with a gluten free diet. Contact a gastro that specializes in Celiac disease
  3. Although itchy skin is typically harmless and treatable, it can sometimes be a symptom of liver disease. Warning signs that itchiness is a symptom of liver disease may include: very itchy skin that..
  4. es the cause by reviewing your medications, your signs and symptoms and, in some cases, other tests and procedures. More common causes of elevated liver enzymes include: Over-the-counter pain medications, particularly aceta

A blockage of the bile duct, caused by the elevation of liver enzymes, usually leads to light or clay colored stools. Itching is also one of the common symptoms that are frequent in people with elevated liver enzymes. Toxins start to build up in the skin and the blood, and in turn provoke this type of sensation Elevated liver enzymes usually have no signs or symptoms on their own. The doctor may check for elevated liver enzymes in patients who might have hepatitis. The symptoms of hepatitis include: Jaundice (a yellowing of the skin, whites of the eyes, and mucous membranes caused by liver problems) People suffering from itch-related liver diseases may have elevated ALP. A simple blood draw is used to measure the amount of alkaline phosphatase enzyme in the bloodstream. Because the causes of itching aren't totally understood, it can be hard to treat and likely won't improve on its own These elevated liver enzymes cause itching which is an indicators of serious liver disease and the cells release the enzymes into bloodstream causing itching. Also remember that due to liver disease, itchy skin at night is possible. the itchiness of the skin worsens during night-time. Also, some forms of blood cancer can cause itchy skin Eczema may be caused by numerous factors. The diagnosis of eczema can be only made by a competent and experienced dermatologist or family doctor. One of the potential causes of eczema may be improper functioning of the liver. This is why liver cleansing may be the best suitable treatment and may help in alleviation of symptoms of eczema

Video: Elevated Liver Enzymes & Itchy Skin Healthfull

Liver Disease and Itching: Causes, Treatment, When to See

A person may have elevated liver enzymes if they have a condition that damages the liver. Learn about the possible causes of elevated liver enzymes and their symptoms and treatment options here Pruritus (itch) is a common complication of cholestatic liver diseases (CLD). It can be a distressing and debilitating symptom, causing significant impairment in quality of life. Treatment of pruritus in liver diseases can be challenging and requires specific management with early initiation and a step-wise approach using specific drugs. Clinical trials are ongoing with novel agents that. can digestive disorders cause elevated alt/ast enzymes, liver is clean according to scan but elevated liver function dizziness & nausea persist 4months? Answered by Dr. Robert Uyeda: Blood tests are: Just that, tests. Scan is an image, a picture. You. Elevated liver enzymes does not necessarily mean cancer. It means your body is fighting something. Cancer could be one of many causes. Everything is filtered though your liver, so many things can cause you to have elevated results

elevated liver enzymes itchy skin Answers from Doctors

Fever, night sweats, and abnormal liver enzymes Ami Schattner, Jacob Gotler A 58-year-old man presented in February, 2014, to the can be a precursor for pyogenic liver abscess as pieces of the infected thrombus break off and seed the liver. In one causes of pyogenic liver abscess, but colonic lesions must be considered,. What can cause a sudden increase in liver enzymes? More common causes of elevated liver enzymes include:Over-the-counter pain medications, particularly acetaminophen (Tylenol, others)Certain prescription medications, including statin drugs used to control cholesterol.Drinking alcohol.Heart failure.Hepatitis A.Hepatitis B.Hepatitis C.Nonalcoholic fatty liver disease.More items•Aug 30, 200 High Liver Enzymes and Your Cancer Risk. High liver enzymes can be a sign of both liver cancer and pancreatic cancer. While fatty liver is a much more likely diagnosis, you should be alert for the signs and symptoms of cancer, especially if tests for fatty liver come back negative. Discuss your health history with your doctor, and either. Inflammation of the liver (raised liver enzymes) Skin problems, including eczema, acne rosacea, rashes or itchy skin. Refractory celiac disease (celiac disease that doesn't resolve on a gluten free diet) Strong sugar or carbohydrate cravings. The excess bacteria and yeast in the small intestine want to be fed If it is not able to process all your dietary toxins they can go to the skin and cause itching. To boost liver health and heal your gut, Dr Cabot prescribes Ultimate Superfood - is a comprehensive formulation, combining potent antioxidants, high quality superfoods, herbs, greens, vitamins and minerals

Itchy skin and elevated Liver enzyme

Elevation in the level of liver enzymes is a sign illustrating the contraction of a specific liver disease. However, such reports must be followed up with a detailed investigation as at times an increase in enzyme levels could turn out to be harmless. The increase in the level of liver enzymes is termed as elevated transaminases or transaminitis Imagine having itchy skin and fatigue with no explanation or diagnosis for your symptoms. had elevated liver enzymes for about four years that they just ignored, Nishele says. Her frustration grew steadily until she was sent to a gastrointestinal (GI) doctor who ran liver tests and made the PBC diagnosis. PBC, a rare autoimmune disease. I have a fatty liver, elevated enzymes and itching at my right shoulder blade also had my gall bladder out almost 2 - Answered by a verified Doctor. We use cookies to give you the best possible experience on our website. dr has given medicine for itching and said a fatty liver can cause itching

The factors contributing to itchy skin in liver disease patients are still not clearly understood. However, based on current studies, it could be due to the following reasons: 1) Bile products being deposited in the skin: Liver diseases such as cirrhosis and hepatitis C often cause blockage of bile ducts. In this case, bile salts could not be. An elevated liver enzyme means there's some damage in your liver cells, and this can make the liver fails to metabolize bilirubin (a byproduct of heme in the hemoglobin) and in turn you will have an elevated bilirubin in your blood and this can cause itching, you will also experiencing jaundice. The rash might have come from your scratching Skin rash and itching; Red, swollen, blistered or peeling skin If you have a history of liver or gallbladder disease, or Always read product labels carefully, since taking a high dose of enzymes can cause side effects. Some people need more pancreatic enzymes than others, so bear in mind the level of each enzyme may need to be altered.

Itch and liver: management in primary car

Living with chronic liver disease could encompass a wide range of health issues, especially if the liver has incurred any significant damage. Regardless of the cause of liver disease, skin itching that goes beyond the feeling of several mosquito bites can be one of the more frustrating manifestations of a struggling liver If our enzymes and bilirubin are in range can we still have itching. I have prickly skin but... Hidden • 12 Replies. ama positive, but normal liver enzymes now. work and found my liver enzymes elevated at 400 and my alkaline phosphatase elevated at 250. the er.. Most liver diseases damage your liver in similar ways and for many, the progression of liver disease looks the same regardless of the underlying disease.Early diagnosis of someone's liver disease may prevent any damage from occurring in the liver. If someone is diagnosed when some scar tissue has already formed, your liver is an incredible organ that can repair or regenerate itself With increasing use, supplements now cause 9% of drug-induced liver injury cases.25 Acetaminophen, another common medication, can cause elevated transaminase levels in therapeutic doses.26, 27. An article published in 2017 revealed that itchy skin is often associated with cholestatic liver disease like primary biliary cirrhosis. The skin is particularly severe on the soles of the feet and palms of hands. Itchy skin is seen mostly in people with primary biliary cirrhosis. Itchy skin is not that common with other types of liver diseases even though those conditions may sometimes cause it

Not all of them, but most of them. Thinning of the haircoat, thinning of the skin itself, a pendulous abdomen (think of a pot-bellied dog), changes in liver enzymes, itchy skin sores, increased susceptibility to infection, lethargy and behavioral changes are some of the signs that can be seen with Cushing's disease High liver count occurs when there is damage to the liver cells, and they begin leaking liver enzymes into the bloodstream. Tests are done to ascertain whether one has high liver count. The normal range for AST is 5 to 40 units per liter, and for ALT is 7 to 56 units per liter of blood serum Hepatitis C affects your liver the most, but it can cause problems with other body parts, too, including your skin. Bumps, rashes , and itchy spots may be the first signs you notice of this infection Warfarin can cause major or fatal bleeding. Regular monitoring of INR should be performed on all treated patients. red, sore, or itching skin; sores, welting, or blisters; unusual drowsiness, dullness, or feeling of sluggishness hepatic dysfunction, hepatitis, cholestatic hepatic injury, liver enzymes elevated . Immunologic. Frequency.

The itching tends to occur early in the course of the disease, when individuals still have good liver function. As a matter of fact, itching can even be the initial symptom of PBC. Do liver problems cause gas? Increased pressure within the blood vessels around the liver can lead to fluid buildup in the abdomen, says Dr. Menon Hi fhame, & a moderate elevation in a single enzyme shouldn't be cause for alarm. Most doc's don't get too excited about elevated liver labs unless they are double or more norm over at least two labs. For reference, viral hepatitis-A can spike enzymes into the thousands, and most of these patients recover without lasting damage Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins. Liver damage. Occasionally, statin use could cause an increase in the level of enzymes that signal liver inflammation. If the increase is only mild, you can continue to take the drug High Liver Enzymes Causes and Symptoms. Elevated liver enzymes can lead to various serious health conditions. In turn, high liver enzyme levels can also be attributed to the following causes. Medications such as cholesterol drugs, pain relievers, and certain antibiotic, anti-seizure, cardiovascular, and antidepressant prescriptions; Alcohol us

I'm by no means an expert on liver functions but, I can tell you this, itching when the liver is being taxed is normal. I see that you're male and therefore you may not know this but, The itch is a common occurrence when a woman is in her final trimester of pregnancy Diets high in fat, sugar, and alcohol can stress the liver and may lead to elevated liver enzymes. Other conditions may also cause elevated liver enzymes, which may come with symptoms like fatigue , weight loss, abdominal pain, dark urine, and itching The pattern of liver enzyme abnormalities can sometimes provide useful clues as to the cause of the liver condition. For example, in a majority of people with alcoholic liver disease, liver enzyme levels are not as high as the levels reached in acute viral hepatitis However, liver enzymes can sometimes measure high on a blood test even if your liver is functioning just fine. Since some medications can cause different patterns of abnormalities, we look very closely at a patient's bloodwork throughout treatment, Megan Kruse, MD, an oncologist at the Cleveland Clinic, tells LIVESTRONG.com Liver cirrhosis, a progressive condition of your liver, can cause high levels of alkaline phosphatase in your blood. According to the National Institute of Diabetes and Digestive and Kidney Diseases, cirrhosis is a condition in which your liver deteriorates over time, eventually malfunctioning due to chronic injury

Most patients with elevated liver enzymes are asymptomatic. Others may experience right upper quadrant pain, fatigue, weakness, and vague viral symptoms such as myalgias and arthralgias. THE LIVER ON HISTAMINE Researchers found that patients with liver disease have chronically elevated histamine levels as a result of mast cell activation. Those in the study had itchy, rashy skin. And as with everything histamine related, it's a case of chicken and egg, because excess blood histamine has been found to cause liver enzyme.

Can b12 cause elevated liver enzymes? Some studies have indicated that elevated serum levels of vitamin B 12 might be a sign of a serious and life-threatening disease. Such falsely high valued of serum vitamin B 12 levels are observed in myeloproliferative disease, acute hepatitis, severe alcoholic liver disease, and cirrhosis If bilirubin levels are high, substances formed when bile is broken down may accumulate, causing itching all over the body. But jaundice itself causes few other symptoms in adults. However, in newborns with jaundice high bilirubin levels (hyperbilirubinemia) can cause a form of brain damage called kernicterus Liver enzymes are constantly fluctuating. I had an ALT as high as 134 two years ago, now it is mid 30s and I have been treating ever since w/ abx. I have found that drinking cleansing/detox teas daily really helps. Personally I don't really recommend NAC as it actually raised my count Acute or chronic inflammation and liver cell damage will cause an abnormally high amount of liver enzymes to leak into the bloodstream. A doctor may order a liver function test or liver chemistries which will reveal protein, enzyme and bilirubin levels in your blood in order to analyze the health of your liver and potential underlying causes of. High bilirubin levels are usually a sign that something's not quite right in your liver or gallbladder. Some of these conditions aren't too serious, but it's important to monitor and treat them

Can elevated liver enzymes cause referred pain in the midsternum area of the chest? I have elevated liver enzymes which was caused by IV antibiotics for 6 weeks due to staph infection in my knee. I have recently stopped the antibiotics due to the elevated liver enzymes but I continue with this intermiitent pain in the middle part of my chest Disorders of the liver, bile duct, or pancreas can cause cholestasis. The skin and whites of the eyes look yellow, the skin itches, urine is dark, and stools may become light-colored and smell foul. Laboratory and often imaging tests are needed to identify the cause. Treatment depends on the cause, but drugs can help relieve itching

Lice can cause a crawling sensation in your scalp or pubic hair, along with an intense itch. See a photo of what bedbug bites look like . Eczema or atopic dermatitis: It shows up on your skin as. Question: I was on a course of Augmentin for a sinus infection.Caused elevated liver enzymes. these are my numbers the day after quitting Augmentin.Quit the drug 2 days ago, these are my labs from yesterday., ALT 459, AST 205, Total Bili 3.3, Direct Bili 2.0, ALk phos157 This condition can cause shortness of breath, fatigue, and swelling of the feet and legs. Since it puts more stress on the liver, it can trigger elevated liver enzymes. Patients may have rapid weight gain from fluid retention, and they may notice a persistent cough. Men are at an increased risk of heart failure Elevated liver enzymes may indicate a problem in the liver and bile duct. Patients may experience loss of appetite and abdominal pain. Various enzymes of the liver are analyzed during the liver function tests.The treatment depends upon the cause of the condition

Rash, Itch, Elevated Liver Enzymes - Allergy - MedHel

If your doctor diagnoses you with elevated liver enzymes, ask them about making dietary changes that might help. For example, you may be able to reduce fatty deposits in your liver by eating lots of leafy green vegetables. You can also support healthy liver function by eating antioxidant-rich foods, such as avocados and walnuts Cholestasis is typically characterized by intense itching on the palms and soles of the feet, dark urine, pain in the upper right quadrant of the abdomen and elevated liver enzymes and bile acid. Causes of Elevated Liver Enzymes in Dogs. Metabolic diseases (obesity) can cause raised liver enzymes in dogs due to fat deposits starting to become deposited on the liver. Diabetes is another cause of elevated liver enzymes in dogs. Thyroid problems can cause the problem. Jaundice is another cause of the condition - your dog will show. Doctors ask which drugs are being taken to determine whether any can cause liver damage. Doctors also do blood tests to measure levels of specific liver enzymes and to evaluate how well the liver is functioning and whether it is damaged (liver tests).Drug-induced liver injury (DILI) is likely when results of liver tests are typical of the liver damage usually caused by a drug that the person.

Elevated liver enzymes are often a result of taking Tylenol or acetaminophen, but alcohol is another common cause of elevated enzyme levels. Discover how vir.. A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer. Aside from altering the eye's appearance, jaundice can cause other symptoms including darkening of the urine, full-body itching, and cognitive impairment. Conclusion The great news is that the liver is a highly adaptive and resilient organ when treated, and is often capable of healing itself Causes of High Alkaline Phosphatase. While alkaline phosphatase may not necessarily cause harm to the body itself, elevated levels are associated with cancer, bone, liver, and kidney diseases [].Additionally, lifestyle factors, medication, and certain supplements can raise alkaline phosphatase levels A damaged liver in a woman may look and feel enlarged. Primary liver damage can be caused by excessive intake of alcohol, leading to cirrhosis of the liver, diabetes, and hepatitis. In addition, gallbladder disease can cause liver damage in women. Although the liver can repair itself, extensive liver damage may be permanent

Liver function test abnormalities occur usually during the second week of illness and resolve within 2-6 weeks. Severe liver problems are rare but can occur and may be deadly. Fulminant cases are usually associated with a concomitant immunodeficiency. Chronic EBV infections may also be implicated with autoimmune hepatitis and hepatocellular. 6 foods to avoid if you have a fatty liver Alcohol. Alcohol is a major cause of fatty liver disease as well as other liver diseases. Added sugar. Stay away from sugary foods such as candy, cookies, sodas, and fruit juices. Fried foods. These are high in fat and calories. Salt. White bread, rice, and pasta. Red meat

Liver disease itching: Causes and treatmen

Many drugs cause mild elevations in blood levels of liver enzymes without symptoms or signs of hepatitis. AST, ALT, and alkaline phosphatase are enzymes that normally reside within the cells of the liver and bile ducts. Some drugs can cause these enzymes to leak from the cells and into the blood, thus elevating the blood levels of the enzymes These are the types of liver disease drugs can cause: Elevated Liver Enzymes - Many drugs cause mild elevations in blood levels of liver enzymes without symptoms or signs of liver disease. Drugs that commonly cause elevations of liver enzymes include aspirin, statins (used in treating high blood cholesterol levels) some antibiotics, some. Slightly elevated liver enzymes is an indication of having a fatty liver. Most people do not even know they have a fatty liver. And it is found incidentally on an ultrasound. A typical scenario is having a gallbladder attack. You wake up in the middle of the night with terrible stomach pain, radiating to the right side or even the right scapula. The itching may be related to allergies, but autoimmune disorders and thyroid problems run in families and they can cause excess histamine release too. (106 replies) (106 replies) Elevated liver enzymes, pain under right rib cage, coarse texture on ultrasoun

Elevated liver enzymes: Causes, symptoms, tests, and treatment

Elevated liver enzymes Causes - Mayo Clini

The most common causes of high liver enzyme levels are: Fatty liver disease. Hepatitis. Drug or alcohol abuse. Certain prescription and over-the-counter medications. Metabolic syndrome. Cirrhosis. While some of the causes of elevated liver enzymes can be chronic, severe liver conditions, that's not always the case Solution. Liver disease can be caused by bacterial or viral infections, heavy alcohol use, toxins, drugs, and autoimmune diseases. Some of these causes can be identified by blood tests; others require sampling of liver tissue under a microscope for diagnosis. In this case, the first set of tests returned an answer Skin flushing. Dizziness. Rapid heartbeat. Itching. Nausea and vomiting. Abdominal pain. Diarrhea. When Spark customers complain to their Advocare Distributor about these symptoms, the complaints are often met with responses such as, Excellent! That means that your body is getting rid of nasty chemicals and toxins built up in your body!

Elevated liver enzymes symptoms Lymphatic & Endocrine

Celiac Disease and Elevated Liver Enzymes . Physicians use a panel of common medical tests to monitor your liver's function, including measurements of the liver enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT). If your liver doesn't function properly due to injury or illness, these tests will show a high result, i.e. Causes. Elevated liver enzymes can be produced by a wide range of factors, some of these being liver disorders, others not. Among the causes are: adrenal deficiency (inadequate hormones produced by the adrenal gland); alcohol abuse; diabetes; elevated triglicerides (a condition often accompanying elevated cholesterol levels); various benign and serious liver diseases, including hepatic. Most hemochromatosis patients have elevated liver enzymes. Although liver disease is the most consistent feature of the disease, hemochromatosis is not an inflammatory liver disease and, therefore, many patients will have normal liver enzymes LIVER DISEASE Liver disease caused by A1AD may occur during infancy, childhood, adolescence, or only newly during adulthood. Symptoms in infancy include prolonged yellow appearance of the skin (jaundice), mildly elevated liver enzymes, and symptoms of cholestasis (e.g., jaundice, dark urine, pale stools and itching)

Elevated Liver Enzymes: Causes & Symptom

Itchy skin; Swollen legs, ankles, and feet there's a recently published case study of a woman developing elevated liver enzymes after going keto, keto can reverse fatty liver, not cause. Hepatitis C is a blood-borne viral disease which can cause liver inflammation, fibrosis, cirrhosis and liver cancer. The hepatitis C virus (HCV) is spread by blood-to-blood contact with an infected person's blood. Many people with HCV infection have no symptoms and are unaware of the need to seek treatment Jaundice likewise causes dark-colored urine and light-colored stools, and the high bilirubin levels it causes can also activate difficult-to-relieve full-body itching. In very severe cases, jaundice can likewise cause a loss of brain function. In older patients, this is frequently misdiagnosed as a dementia-related disorder. Dealing with liver.

Top Causes of Elevated Liver Enzymes + How to Treat High

Itching: An Unknown but Not Uncommon Sign of Liver Diseas

Elevated liver enzymes could be an indicant of something amiss in the function of the liver. Know what this condition means from the article compiled below. Certain conditions like damage to or inflammation of the liver cells could be indicated by liver enzyme levels. Liver cells, when they are injured, tend to leak amounts of certain chemicals. Many people with autoimmune hepatitis respond well to prednisone treatment, which can relieve symptoms and cause elevated liver enzyme levels to return to normal. Autoimmune hepatitis is a condition that needs monitoring over the long term, as it can lead to cirrhosis and ultimately, the need for a liver transplant Answer: Elevated liver enzymes, itching, jaundice after tummy tuck cosmetic surgery I have had occasion to observe a similar elevation of liver enzymes in 2 patients who underwent cosmetic surgery who ultimately underwent extensive testing including liver biopsies and were similarly diagnosed with an adverse antibiotic reaction *Different infections, toxins, medications, and a host of other causes can cause elevation of liver enzymes * Almost any drug would cause liver inflammation * Hepatitis A, b or C. * Over-the-counter pain medications, including acetaminophen (Tylenol, others) * Autoimmune Hepatitis * Cirrhosis * CMV(Cytomegalovirus ) infecion * Epstein -Barr Viru Autoimmune hepatitis is a chronic condition and can lead to liver damage, which causes elevated liver enzymes (ALT/AST). There are two forms of autoimmune hepatitis: type 1 (most common form) and type 2. The mainstays of treatment for autoimmune hepatitis are agents that suppress the immune response to the liver

Liver Disease That Cause Itching - Health CheckU

Elevated liver enzymes often indicate inflammation or damage to cells in the liver. Inflamed or injured liver cells leak higher than normal amounts of certain chemicals, including liver enzymes, into the bloodstream, elevating liver enzymes on blood tests. What medications can cause liver enzymes to be elevated? More common causes of elevated. High liver GGT enzymes can hint at a toxic liver. Alcohol in excess will cause liver toxicity and can cause a rise in GGT enzymes in a liver test. However high GGTs can also be caused by two other common toxic byproducts. One is certain medications. Many pharmaceutical drugs need to be metabolized though the liver, and can therefor cause a rise. Itching is also one of the common symptoms that are frequent in people with elevated liver enzymes. High liver enzyme count. When the liver is inflamed it releases more chemicals than normal which can be seen in a blood test. The size of the liver varies with age sex and body size.. The size of the liver varies with age sex and body size. Other.

Eczema and liver functioning Skin & Hair problems

When the liver is not functioning properly, oestrogen in the system increases. This causes a substance named tyrosinase, an enzyme containing copper, to produce more melanin (skin pigmentation) and causes blemishes on the face or the entire body. 6. Red palms . Red, burning itching hand palms, also known as palmar erythema, can be a sign of. Correspondingly, can Crohn's disease cause elevated liver enzymes? BACKGROUND: Abnormal liver enzymes are frequently encountered in inflammatory bowel disease (IBD) patients. Infliximab has been implicated in inducing drug-induced liver injury, autoimmune hepatitis or reactivation of hepatitis B virus Besides, can b12 cause liver damage? Vitamin B12 and your liver health Liver disease can cause B vitamin deficiencies, mostly due to poor diet. However, you might also be missing out on this valuable vitamin.Even if you are getting it in your diet, B12 does not absorb well in the intestine if you have cirrhosis, or stage 3 or 4 liver disease. Secondly, what happens if your b12 is too high

Dental Patients with Liver Disease(PDF) ELEVATED LIVER ENZYMES IN PATIENTS WITH CHOLECYSTITISAtlas of Liver Biopsies | Basicmedical Key

Hi, I had my gallbladder out in 2007' with was apparently stuck to my liver, and they had to do a bit of chopping about. my GP retired so was given a new GP, he ask why my liver levels were high ( I had no idea levels were high) and that they had been high for past 3 years, he started running tests, I had a liver biopsy also and was diagnosed with PBC in 2010.. Without treatment, chronic Hepatitis C can cause chronic liver disease, cirrhosis, liver failure or liver cancer. Chronic hepatitis B is a long-lasting viral infection that occurs when the body is unable to fight off the hepatitis B virus, causing liver inflammation and damage Some meds can cause high liver enzymes. Methotrexate is one of them but I don't know about sildenifel. Does your wife get regular blood work checks? There is a risk with limited systemic scleroderma for PBC - an autoimmune liver disease with high enzyme levels being once of the indications Elevated alkaline phosphatase in dogs is a common finding when dogs undergo blood tests. In order to better understand the meaning of elevated alkaline phosphatase, it helps gaining a deeper insight into what alkaline phosphatase is and what role it plays in your dog's body Causes of Elevated Liver Enzymes There are several diseases or conditions that can cause elevated liver enzymes. These diseases may be liver diseases or diseases not associated with the liver such as jaundice, pancreatitis, Cushing's disease, infectious hepatitis, diabetes, hypothyroidism and heartworm infection