CD44 pathology outlines

Pathology Outlines - CD44

Discriminatory immunohistochemical staining of urothelial

  1. CD34+ fibroblastic cells. Pseudoangiomatous hyperplasia (PASH) of breast: stroma is CD34+. Solitary sclerotic fibroma, finger. Spindle cell lipoma. has CD34+ stroma: breast (left); salivary. glands (right, fig D) Superficial acral fibromyxoma, soft tissue, F2. CD34 distinguishes displaced epithelium
  2. ant and negative. Another panel. Another panel for benign urothelium versus CIS: CK20 +ve in deep cells (23/26 cases). Normal urothelium -- only the umbrella cells. Ki-67 ~50% of cells - deep and superficial. Normal ~10% of cells, confined to basal aspect. CD44 -ve. Positive in indeter
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  4. CD Markers - CD43. T/NK cell lymphomas - anaplastic large cell (variable), CD4+/CD56+ hematodermic neoplasm / blastic NK (Am J Surg Pathol 2005;29:1274), hepatosplenic gamma-delta T cell, NK/T cell-nasal type (96%, Hum Pathol 2004;35:86), peripheral T cell, subcutaneous panniculitis-like ; B cell lymphomas - ALL (most), Burkitt's (almost all), Burkitt's-like (almost all, Am J Surg Pathol.
  5. g a platelet plug

Eleven uvular biopsies were investigated for their morphology, the presence of mast cells and the distribution of hyaluronan and its major ligand CD44. Three microanatomical sites--surface epithelium, subepithelial area and area of glands--were examined. The oral side of the uvula was covered by a 1 CD44. In one of the cases of pagetoid CIS, CK20 and p53 stained only the neoplastic cells within the adja-cent benign reactive epithelium, although the benign reactive epithelium showed strong membrane reactivi-ty with CD44, as might be expected. In the March 2003 issue of Modern Pathology, Mallofre and associates from the University o The 2004 World Health Organization classification system for urothelial neoplasia identifies urothelial dysplasia (low-grade intraurothelial neoplasia) as a premalignant lesion of the urothelium. Although diagnostic criteria of urothelial dysplasia have been improved in recent years, there is a freq T cell factor-1 (TCF1) critically regulates T cell development. However, signals that control TCF1 function in developing and mature T cells remain unknown. TCF1 along with beta-catenin activates gene transcription and in cooperation with Groucho family of proteins mediates gene repression. It has b Small cell lung cancer, a subtype of lung cancer is an extremely malignant disease due to its metastases and recurrence. Patients with SCLC develop resistance to chemotherapy and the disease relapses. This relapse and resistance are attributed to the heterogeneity of SCLC. Various factors such as re


Basal cell carcinoma (BCC) is the most common malignant neoplasm in the skin and is considered to have a low degree of malignancy. BCC is invasive but rarely metastatic and originates in hair follicle-derived cells or interfollicular zones of the epidermis. Trichoblastoma (TB) is an infrequent. Background: One hundred forty nine stromal nodules (SNs) from transurethral resection of benign prostatic hyperplasia specimens in 39 patients (57-85 years with mean of 70.9) were investigated to characterize the SNs and to outline the etiopathogenesis of solitary fibrous tumors (SFTs) and gastrointestinal stromal tumors (GISTs) of prostate by immunohistochemistry performed on tissue. cytokeratin 20, p53 and CD44 antigens. Am J Surg Pathol 2001;25:1074-78 Mallofré C et al. Imunohistochemical expression of CK20, p53 and Ki-67 as objective markers of urothelial dysplasia. Mod Pathol 2003;16:187-191 Hodges KB et al. Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features Geoffrey Strutton, in Weedon's Skin Pathology (Third Edition), 2010. MANTLE CELL LYMPHOMA. The majority of cases classified as mantle cell lymphoma (MCL) in the skin are secondary to nodal disease. 932 Secondary skin involvement has been reported in up to 17% of cases of advanced disease. 933 Cutaneous lesions may be the first manifestation of the disease. 61 Urothelial dysplasia and carcinoma in situ (CIS) are related to recurrence and progression of urothelial carcinoma. Distinguishing CIS and dysplasia from reactive atypia is often difficult on the basis of histological features alone. Cytokeratin 20 (CK20), p53, and Ki-67 are related either to neopla

CD7 is a transmembrane glycoprotein and a member of the immunoglobulin supergene family. It plays an important role in T-cell and T-cell/B-cell interactions during early lymphoid development. CD7 is the earliest T-cell-associated molecule to appear in stem cells and prethymic stages and extends its expression all the way to the mature T cells Simon RA, di Sant'Agnese PA, Huang LS, Xu H, Yao JL, Yang Q, Liang S, Liu J, Yu R, Cheng L, Oh WK, Palapattu GS, Wei J, Huang J. CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers. Hum Pathol. 2009 Feb;40(2):252-8 ers for Ewing sarcoma, but their accuracy has been controversial. NKX2.2 is a homeodomain-containing transcription factor that plays a critical role in neuroendocrine/glial differentiation. The NKX2.2 gene was recently identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based. It is the most common tumor of women and the most common tumor of the uterus. These tumors may present with pain, irregular and excessive uterine bleeding, urinary disturbances, or constipation. These tumors sometimes declare themselves during pregnancy and may be associated with abruptio placentae, pain, and premature labor The American Journal of Pathology 180 (4):1509-21. 2012/04 [Full Text Article] [Pubmed: 22349300] [PMC: PMC5426554] Arora, Arvind et al. RECQL4 Helicase Has Oncogenic Potential in Sporadic Breast Cancers. The Journal of Pathology 238 (4):495-501. 2016/03 [Full Text Article] [Pubmed: 26690729] [PMC: PMC5576893

  1. Cytokeratins belong to the family of intermediate filaments. They are expressed in a highly specific manner in epithelial cells where they play a crucial role in the integrity and mechanical stability of the cells. Several types of cytokeratins have been described in normal as well as neoplastic urothelium. In the case of urothelial neoplasms expression of CK20 and CK5/6 has been shown in.
  2. e more significant biomarkers of LCS, we studied the expression and distribution pattern of Wilms tumor 1 (WT1) and cluster of differentiation 44 (CD44) in LCS. A broad panel of antibodies was used for immunohistochemical technology. Simultaneously, dual immunofluorescence staining.
  3. ), both involved in renal fibrosis, can operate as surrogate markers for late IF/TA and renal function. Furthermore, we wanted to establish the interrater reproducibility for the scoring system, which can be a problem in histologic assessments. Methods.Six-month protocol renal allograft biopsies (n=30 for matching 12 months estimated glomerular filtration rate (eGFR) from which 20 matched the.

Pathology Outlines - CD3

To examine the diversity of astrocytes in the human brain, we immunostained surgical specimens of temporal cortex and hippocampus and autopsy brains for CD44, a plasma membrane protein and extracellular matrix receptor. CD44 antibodies outline the details of astrocyte morphology to a degree not possible with glial fibrillary acidic protein (GFAP) antibodies. CD44+ astrocytes could be. Disseminating epithelial ovarian cancer cells often become assembled into spheroids prior to their arrival at metastatic sites within the peritoneal cavity. Although epithelial ovarian carcinoma (EOC) is the deadliest gynecologic malignancy, the mechanisms regulating formation and metastatic potential of spheroids are poorly understood. We show that expression of a cell surface glycoprotein. CD44 is present on the surface of many vertebrate cells, such as chondrocytes, lymphocytes, many types of epithelial cells, fibroblasts, smooth muscle cells and a subset of glial cells in the central nervous system 7. The human CD44 gene is encoded by a single, highly conserved gene with a length of 50-60 kb and is composed of 20 exons8, 9. Gliomas are the most frequent primary central nervous system neoplasms. Cancer stem cells have been implicated in tumor initiation, progression, metastatic potential and resistance to therapy. Aim of this study is determination of CD44 and CD133 expression level as cancer stem cell markers in different gliomas comparing to normal brain tissue and its correlation with tumor grade

Urothelial carcinoma in situ - Libre Patholog

  1. We identified chondrocytoid cells that produced hyaluronic acid in 23 (61%) fingers and hypocellular collagen matrix in 32 (84%) fingers around the tenosynovium among 38 specimens of tenosynovium from patients with trigger fingers. These chondrocytoid cells expressed the synovial B cell marker CD44, but not the chondrocyte marker S-100 protein
  2. cytokeratin 20, p53 and CD44 antigens. Am J Surg Pathol 2001;25:1074-78 Mallofré C et al. Imunohistochemical expression of CK20, p53 and Ki-67 as objective markers of urothelial dysplasia. Mod Pathol 2003;16:187-191 Hodges KB et al. Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features
  3. ology of premalignant endocervical glandular lesions is discussed because of the differences between the UK ter
  4. ance of tumor promoting inflammation. Given the accumulating evidence that the microenvironment supports tumor growth, we investigated hyaluronan (HA)-CD44 interactions within breast cancer cells, to deter
  5. CD44, a surface marker for cancer stem cells, interacts with PKM2, a key regulator of aerobic glycolysis, and enhances the glycolytic phenotype of cancer cells leading to antioxidant protection and macromolecules' synthesis. To clarify the clinical importance of this cross-talk as a mechanism of drug resistance, we assessed the expression both of PKM2 and of CD44 in cancer cells of.
  6. pathology *March 2013, Bal more, MD *Useful IHC markers of urothelial differen a on *Specific applica ons for urothelial markers (and their pi alls) *Evidence-based recommenda ons on what markers to use and whe

Pathology Outlines - PathologyOutlines

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CD44 is the cell surface receptor for hyaluronate (HA). We demonstrated that the lack of CD44 expression in murine keratinocytes leads to an abnormal HA accumulation in the dermis, indicating an important role of CD44 in local HA metabolism in mouse skin. We also observed a decrease in the expression of epidermal CD44 in patients of lichen sclerosus et atrophicus which is potentially. Expression of androgen receptor, gross cystic disease fluid protein, and CD44 in salivary duct carcinoma. Kapadia SB(1), Barnes L. Author information: (1)Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania, USA Of note, as mentioned above, CD44 is processed by γ-secretase activity, which is of relevance to AD pathology [85]. The expression of CD44 antigen is also useful for characterizing neural stem/progenitor cells. The presence of CD44 in the majority of human embryonic stem cells (hESCs), NSC contaminants, and neural ectoderm-depleted embryoid.

Structure of the human uvula - PubMe

(1) Background: The aim of the study was to evaluate the prognostic significance of EMT-associated (TWIST1) and stem-cell (SC) transcript (CD24, CD44, ALDH1) quantification in EpCAM+ circulating tumor cells (CTCs) of early breast cancer patients. (2) Methods: 100 early stage breast cancer patients and 19 healthy donors were enrolled in the study. CD24, CD44, and ALDH1 transcripts of EpCAM+. Cluster of differentiation (CD) 44v6 is the isoform of CD44, a cell surface membrane glycoprotein that plays a role in the regulation of cell-cell and cell-matrix interactions as well as cell migration. 181 Expression of CD44v6 has been reported in several carcinomas. 182-185 Few studies investigating CD44v6 expression in thyroid lesions. A biologic subset of diffuse large B-cell lymphomas with a unique molecular signature or expression profile. It represents approximately 30% of diffuse large B-cell lymphomas, and is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes. Morphologically, these lymphomas are either centroblastic or immunoblastic (ratio 2:1)

Aim Phyllodes tumours (PTs) categorised as benign, borderline and malignant, account for 1% of all breast tumours. Histological assessment does not always predict tumour behaviour, hindering determination of the clinical course and management. Epithelial-mesenchymal transition (EMT) is an important process during embryogenesis. Dysregulation of EMT causes loss of cell polarity, decreased. A molecular pathology-based classification for HA has been established, dividing HAs into subtypes based on their molecular characteristics, as determined by the corresponding immunohistochemical profiles and histomorphological characteristics. 74,75 The established HA subtypes are (1) HAs with mutated, inactive HNF1A, (HA-H), (2) HAs with. Thyroid nodules are frequent in general population, found in 3.7-7% of people by palpation and 42-67% by ultrasonography (US). The differential diagnosis ranges from papillary (PC), follicular (FC) and medullary (MC) carcinomas to follicular adenoma (FA) and colloid goitre. Cancer risk in thyroid nodules varies: 5% in masses found by palpation, 1.6-15% by US, 3.9-11.3% by computed.

CD44 expression was also stable in CD44+CD133+ (double positive) cells across the four independent PDGCs , (p-value 7.94e-4). The CD44-CD133+ subpopulation did not exhibit a statistically significant deviation from equal proportions, compared to the unsorted controls . There was a trend for CD44-CD133+ cells to retain expression of CD133, with. Klimstra DS, Modlin IR, Adsay NV, et al. Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set. Am J Surg Pathol 2010;34:300-13. Klimstra DS, Modlin IR, Coppola D, et al Briana C. Gleason MD, Jason L. Hornick MD, PhD, in Practical Soft Tissue Pathology: a Diagnostic Approach (Second Edition), 2019 Immunohistochemistry. CD31 is positive in more than 90% of angiosarcomas, and the staining pattern is distinct and membranous, in contrast to the weak cytoplasmic staining reported in a small number of adenocarcinomas and mesotheliomas. 1 CD31 is fairly specific for. Initially, Fogel et al reported that primary breast cancer in humans are positive for CD24. 143 Subsequently, it was shown that the ability of primary breast cancer cells to form tumors in NOD/SCID mice was far greater in the CD44 + CD24-fraction compared to the CD44+/CD24+ fraction. 7 Owing to this enhanced tumor-forming ability, the CD44.

Urothelial dysplasia of the bladder: diagnostic features

Recently, we reported the involvement of TIPRL/LC3/CD133 in liver cancer aggressiveness. This study assessed the human TOR signaling regulator (TIPRL)/microtubule-associated light chain 3 (LC3)/prominin-1 (CD133)/cluster of differentiation 44 (CD44) as potential diagnostic and prognostic biomarkers for early liver cancer. For the assessment, we stained tissues of human liver disease/cancer. We also examined two markers of breast CSC subtypes, CD44 and ALDH. These markers varied from 0 to 90% of tumour cells in different tumours (see supplementary material, Table S3). ΔNp63/p40 + cells were never ALDH +, but a subset of CD44 + cells were ΔNp63/p40 + (Figure 1E,F) Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Krause DS, Lazarides K, von Andrian UH, Van Etten RA. Nat Med. 2006 Oct;12(10):1175-80. Epub 2006 Sep 24. PMID 16998483 : The molecular pathology of chronic myelogenous leukaemia. Kurzrock R, Talpaz M. Br J Haematol. 1991 Oct;79 Suppl 1:34-7. PMID 193170 The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. In terms of physiology, CD molecules can act in numerous ways, often acting as receptors or ligands important to the cell

Pathology Outlines - Adenosquamous carcinoma

Astrogliosis in HS (A, G, I) and cortical tubers (B-F, J) has many similar features.A: Upregulation of GFAP and very low levels of GS and EAAT2 expression in sclerotic CA1 in HS.The border with nonsclerotic hippocampus is marked by dotted line. B, C, D: Demarcation between cortical tubers and perituberal tissue.Similar changes in GFAP, GS, and EAAT2 immunostaining were seen in tubers and HS CD31. Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. PECAM-1 plays a key role in removing aged neutrophils from the body The CD117 protein is a transmembrane, tyrosine kinase growth factor receptor that is the product of c-kit gene expression. It is present in a variety of normal human cell types, including breast epithelium, germ cells, melanocytes, immature myeloid cells, and mast cells. 376,377 Staining for CD117 occurs in a variety of tumor types, although. rcinoma patients, indicating the need for the identification of molecular markers for this tumour type. Aim The aim of the study was to clarify the role of extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147), CD24 and methylation of p16 promoter in the genesis and progression of gastric carcinoma. Materials and methods Expression of EMMPRIN (CD147) and CD24 was examined.

It is often difficult to diagnose salivary gland tumors that exhibit basaloid features differentially. The aim of this study was to identify additional morphological and immunohistochemical characteristics that can aid the diagnosis of basal cell adenocarcinoma (BCAC) of the salivary gland. In total, 29 basal cell neoplasms [eight BCACs, 11 basal cell adenomas (BCAs) with capsular invasion. It provided experimental evidence indicating that MARCH8 acted as a tumor suppressor by inhibiting breast cancer metastasis and enhancing cancer cell death. Mechanistically, MARCH8 promoted lysosomal degradation of the breast cancer stem cell marker CD44, and simultaneously it induced STAT3 degradation via the proteosome-dependent pathway Download Stains by CPT Code 88342 88342:(Global Only) 88312 88313 88365 (in-situ hybridization) Double-Stains Triple-Stain Panels Immunogloblun G (IgG) 88342 Adenovirus Adrenocorticotropic hormone (ACTH) Alk-1 protein Alpha 1 antichymotrypsin/A1ACT Alpha [ INTRODUCTION. The last few years have witnessed a remarkable increase in our understanding of neuro-oncology. These advances have enabled neuropathologists to diagnose and classify tumors more accurately and to guide care through improved prognostic estimation and prediction of therapeutic responses (1, 2).In this context, immunohistochemistry offers an affordable, powerful, and readily.

Gene ID: 4804, updated on 5-Jul-2021. Summary. Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain Introduction. CD44/CD44 variant isoforms (CD44v) are adhesion molecules also described as most prominent function-relevant cancer initiating cell (CIC) markers (Zöller, 2011; Yan et al., 2015).To shed light on the engagement of CD44/CD44v6 in CIC activities, we will first introduce the CD44 molecule, CIC and exosomes (Exo) and then outline the state of knowledge on the linkage between CD44. the Kumamoto University Hospital. The association between the expression of CD44 variant 6 and distant metastasis was evaluated based on a large-scale immunohistochemical analysis. Primary ovarian tumors that contained at least 10% CD44 variant 6-positive cancer cells were categorized as CD44v6-high (n=53), and the tumors that contained less than 10% CD44 variant 6-positive cells were. CD44 is a cell surface marker that has been linked to CSC populations in many solid tumors, though data is conflicting on its role as tumor suppressor or oncogene. Gastrointestinal stromal tumors (GIST) is an increasingly common malignancy where risk stratification is essential for guiding post-surgical adjuvant therapy CD44 is a transmembrane glycoprotein of 85 kDa (742 aa) encoded by the CD44 gene located on chromosome 11. CD44 exists in more than 20 isoforms due to RNA alternative splicing, giving rise to different proteins in different cancer tissue subtypes

TCF1 and beta-catenin regulate T cell development and

  1. An abstract is unavailable
  2. CD44 CD45 (LCA) cMET Surgical Pathology Consult. Add NeoTYPE Profile if indicated. Consultation - A NeoGenomics pathologist will select medically necessary tests with any exception noted below by the client to provide comprehensive analysis and professional interpretation for the materials submitted. Performed on FFPE only
  3. Furthermore, 41% of ER + /PR + and/or HER2 + locally metastatic breast cancers expressed ΔNp63/p40, and these cells commonly accounted for <1% of the metastatic tumour cell population that localised to the tumour/stroma interface, exhibited an undifferentiated phenotype and were CD44 + /ALDH −
  4. A potentially useful immunohistochemical panel includes CK20, p53, and CD44. 48 The typical staining patterns are outlined in Table 4. Cytokeratin 20 is one of the most useful markers. In normal and reactive urothelium, CK20 expression is seen only in umbrella cells
  5. Recommended IHC Control Tissue This is JMD Histologistics growing list of tissue necessary for antibody staining. We do not in any way attest to the tissue working perfectly for everyone. With the varied amount of antibodies and their manufacturers, control tissue types should be found through antibody data sheets. This is an ongoing list, it starte

It is well established that CD4-CD8-T cell precursors migrate to the thymus where they undergo the following phenotypical stages: CD44 + CD25-(DN1), CD44 + CD25 + (DN2), CD44-CD25 + (DN3), and CD44-CD25-(DN4), followed by the progression of DN4 cells into the double-positive CD4 + CD8 + T cells [] (Figure 1).Infection by various pathogens causes activation and proliferation of naïve T cells. Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle.Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system e16564 Background: CD44, a surface marker for cancer stem cells interacts with PKM2, a key regulator of aerobic glycolysis and enhances the glycolytic phenotype of cancer cells that, subsequently, leads to increased glutathione levels and decreased ROS accumulation. To explore the clinical importance of this interaction as a mechanism of drug resistance, we assessed the expression of PKM2 and. Breast cancer cells with a CD44 + /CD24 −/low phenotype have been proposed to have tumor-initiating properties, and this tumorigenic phenotype is considered a stem cell-like feature. 55 Li et al 51 demonstrated that the ratio of CD44 + to CD24 −/low tumor cells was higher in IMPCs than it was in IDC-NOS, and the increased CD44 + to CD24. Hairy cell leukemia is a rare, slow-growing cancer of the blood in which your bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. These excess B cells are abnormal and look hairy under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and.

Heterogeneity of Small Cell Lung Cancer Stem Cell

Primary central nervous system lymphoma (PCNSL) is the most prevalent brain, spinal cord, eyes, and leptomeningeal lymphoma. It is often misdiagnosed due to an unspecific presentation or unavailable biopsy and results in a poor prognosis. Although the craniocerebral imaging examination of PCNSL has some characteristics, it is limited, and atypical cases are especially difficult to identify. Animation of skin wound inflammation.Created by Drew Berry for E.O.Wilson's Life on Earth interactive textbook of biology (2014) available free from iBook Stor Objective— The importance of the extracellular matrix molecules versican, biglycan, decorin, and hyaluronan in plaque instability has not been recognized. Methods and Results— Coronary lesions with acute thrombi and stable plaques were examined for the accumulation and distribution of specific proteoglycans and hyaluronan at culprit sites. The cell surface receptor for hyaluronan, CD44. Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan (HSPG, i.e. Heparan Sulfate ProteoGlycan) in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. It is in this form that HS binds to a variety of protein ligands, including Wnt, and regulates a wide range of biological activities.

Immunohistochemistry Panel for Differential Diagnosis of

In contrast, there is loss of expression of CD44 in dysplasia and CIS. 184 Other markers that have been applied to this challenge include p16 and E-cadherin, but there is less experience with these, making their routine use of limited value. 202, 203 In one study, E-cadherin showed more diffuse and intense immunoreactivity in CIS than in normal. To further verify the relationship between CD44 and caspase-1/IL1B, Q-PCR analysis was performed in 50 HCC tissues, and we confirmed that CD44 was positively associated with CASP1 and NLRP3 (Fig. 1d) Histiocytoid breast carcinoma is an uncommon entity that is mostly regarded as a variant of lobular carcinoma. Its occurrence with apocrine lobular carcinoma in situ and consistent expression of gross cystic disease fluid protein 15 suggest apocrine differentiation. Its recognition is often challenging, particularly when histiocytoid tumour cells occur in a metastatic site before the primary. Metaplastic breast carcinoma is a rare entity of breast cancer expressing epithelial and/or mesenchymal tissue within the same tumor. The aim of this study is to evaluate the clinicopathological features of metaplastic breast carcinoma and to confirm the triple negative, basal-like and/or luminal phenotype of this type of tumor by using immunohistochemical staining

Pathology Outlines - Basophils

(B) CD44 protein expression in MDCK cells that underwent EMT by transfection of E-cadherin repressors Snail 1, 2, and E47. (C) CD44 and podoplanin protein expression in mouse normal epidermis and skin tumors induced by two-stage carcinogenesis. All squamous cell carcinomas (SCCs) were excised at 43 wk post-initiation Use in pathology and research Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells and myocytes. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes , histiocytes , giant cells , Kupffer cells , and. Bladder leiomyosarcoma is the most frequent mesenchymal neoplasm of the bladder. However, the rarity of the disease and some morphological aspects could give serious problems to differential diagnosis. A 86-year-old male patient was referred to our institution to undergo endoscopic low-urinary-tract re-evaluation 2 months after the detection of a low-grade urothelial neoplasia in urinary. Urothelial carcinoma in situ (CIS) is a high-risk subtype of non-invasive bladder cancer that has a substantial rate of invasion and death, with a 5-year risk of progression up to 45% [1,2,3].However, if appropriate intervention is made, risk of progression is significantly reduced with improved disease-free survival [].It is important to accurately identify this lesion in a timely manner so.

Stromal nodules in benign prostatic hyperplasia

The following outline is provided as an overview of and topical guide to immunology: . Immunology is the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency. Executive Bio Phone: (901) 448-7020 Email: mamin5@uthsc.edu View Dr. Mahul Amin's profile the American College of Surgeons, Commission on Cancer center accreditation program in the United States and the CAP's laboratory accreditation program. In 2013, he was appointed as Editor-in-Chief of the 8th edition of the American Joint Committee on Cancer (AJCC) staging manual where h Gastrointestinal Stromal Tumours Dr Priyageet Kaur. 2. Introduction • Gastrointestinal stromal tumors (GISTs) constitute a majority of mesenchymal neoplasms of the gastrointestinal (GI) tract and abdomen. • Pathologic activation of KIT signal transduction appears to be a central event in GIST pathogenesis. 3 Subramaniam, Gardner, Jothy: Soluble CD44 secretion contributes to the acquisition of aggressive tumor phenotype in human colon cancer cells. in: Experimental and molecular pathology, Vol. 83, Issue 3, pp. 341-6, 2007 . Target Details for CD44 (hide) Target CD44 3.2. Expression of ABCG2, CD133, Podoplanin, and Ki-67 in ACC. ABCG2. ABCG2-positive stainings could be detected in 23 cases including 1 case of weak staining intensity, 7 cases of moderate intensity, and 15 cases of strong intensity, and the positive expression percentage was 92% (Table 2).The tumor cells showed strong ABCG2 staining in the invasive front of cancer nests and the intensity in.

CD43 - an overview ScienceDirect Topic

CD44-positive glomeruli were quantified by the incidence of glomeruli having CD44 + cells. Similar to p57, we analyzed CD44 + glomeruli among all the glomeruli encountered in each section (on. Toward this aim, we have identified a small molecule A2512, which selectively depletes the CD44+/CD24-/low stem cell subpopulation in breast cancer cells. Ongoing studies in the lab are focusing on determining the mechanisms by which A2512 inhibits CSC self-renewal and evaluating its potential to eradicate CSCs in tumor tissues using. Proposed models of human breast cancer progression. The ductal and lobular subtypes constitute the majority of all breast cancers worldwide with the ductal subtype accounting for 40-75% of all diagnosed cases [7, 8].Epidemiologic and morphologic observations led to the formulation of several linear models of breast cancer initiation, transformation and progression as depicted in Figure 1 To determine whether 18F-FSPG uptake in lung cancer can be predicted based on correlation with CD44 and amino acid transport system xc- (xC-) expression in surgical pathology specimens. OUTLINE: Patients undergo 18F-FDG PET/CT scan per standard of care. Within 15 working days, patients also undergo 18F-FSPG PET scan over 60 minutes followed by.

Pathology Outlines - Erythroid maturation (erythropoiesis)Pathology Outlines - Osteoblasts

The diagnosis of tumors of the urinary bladder and urinary tract account for 6% of new cancer cases in men and 3% of new cancer cases in women in the U.S. each year ().Two distinct clinical forms of the disease are recognized: noninvasive or superficially invasive typically low-grade papillary tumors with a favorable prognosis and flat tumors often of high histologic grade detected. Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cellular homolog of the. S.-C. Ming: Pathology and genetics of gastric cancer 31Gastric Cancer (1998) 1: 31-50 Review article Cellular and molecular pathology of gastric carcinoma and precursor lesions: A critical review Si-Chun Ming Department of Pathology and Laboratory Medicine, Temple University School of Medicine, 3400 North Broad Street, Philadelphia Department of Pathology, School of Medicine, University of California, San Francisco 94143. Blood 1988 May;71(5):1329-33 Abstract quote Follicular mucinosis is a condition characterized by the abnormal accumulation of acidic mucopolysaccharides in hair follicles Core tip: Paneth cells physiologically locate in small intestinal crypts. Wnt signalling promotes their differentiation and movement into crypts, whereas Notch activities antagonise Paneth cell maturation. The cells essentially contribute to crypt morphogenesis and intestinal homeostasis, sharpening the microbiome by secreting antimicrobial peptides, like defensins, and crypt fission It has been estimated that the ratio of NB to GN is approximately 6:1 to 10:1 (, 110 111 ). GN occurs in the same anatomic locations as NB and GNB, although at different frequencies. The most common locations are the posterior mediastinum (41.5% of cases), retroperitoneum (37.5%), adrenal gland (21%), and neck (8%)