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Pathogenesis of Neisseria meningitidis SlideShare

Neisseria meningitidis

Neisseria meningitidis: pathogenesis and immunit

  1. The recent advances in cellular microbiology, genomics, and immunology has opened new horizons in the understanding of meningococcal pathogenesis and in the definition of new prophylactic intervention. It is now clear that Neissera meningitidis has evolved a number of surface structures to mediate i
  2. Neisseria meningitidis (the meningococcus) causes significant morbidity and mortality in children and young adults worldwide through epidemic or sporadic meningitis and/or septicemia. In this review, we describe the biology, microbiology, and epidemiology of this exclusive human pathogen. N. meningitidis is a fastidious, encapsulated, aerobic gram-negative diplococcus
  3. Pathophysiology. Meningitis is a disease process where the protective layers that cover the brain and spinal cord become inflamed. Meningitis can be infectious or it can be caused by injury, cancer, and other noninfectious causes. Infectious meningitis can be caused by a bacterial, viral, or fungal infection
  4. Laboratory Methods for the Diagnosis of Meningitis Caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. Second edition (2011) This manual summarizes laboratory techniques used in the isolation and identification and characterization of Neisseria meningitidis (the meningococcus), Streptococcus pneumoniae (the pneumococcus) and Haemophilus influenzae from the.
  5. There are 5 pathogenic serogroups (A,B,C,Y and W135) based on chemical composition of distinctive capsular polysaccharide typing. Although the vaccine exists, its impact has been limited. Comparative Genomics: key to identify the genes responsible for pathogenesis of meningitis Complete genomes of 2 strains of Neisseria meningitidis are available
  6. A variety of organisms including different bacteria, fungi or viruses, can cause meningitis. Neisseria meningitidis (Nm, the meningococcus) is a leading cause of bacterial meningitis throughout the world. Besides meningitis, meningococci can cause sepsis, pneumonia and, occasionally, focal infections such as arthritis, myocarditis, pericarditis, endophthalmitis, epiglottitis, otitis and.
  7. Meningitis is a disease caused by the inflammation of the protective membranes covering the brain and spinal cord known as the meninges. The inflammation is usually caused by an infection of the fluid surrounding the brain and spinal cord. Meningitis is also referred to as spinal meningitis

Neisseria meningitidis: Biology, Microbiology, and

Neisseria species and 3 subspecies of which may be isolated from humans and animals1. Four species have been reclassified1,2. The clinically important Neisseria species (Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria lactamica and Neisseria cinerea) are relatively easy to identify from the non-pathogenic Neisseria The Neisseria genus is composed of many commensals and one other pathogen, Neisseria meningitidis, that are closely related to N. gonorrhoeae genetically but are phenotypically distinct and occupy. 87 Pathogenesis of Bacterial Infection MICROBIOLOGY MODULE Microbiology Notes zdifferentiate colonization and pathogens zexplain steps involved in the bacterial pathogenesis zdescribe toxins zdifferentiate endotoxins and exotoxins zdiscuss the various diseases caused by bacteria 8.2 PATHOGENICITY Pathogenicity is the capacity to initiate disease Pathophysiology of meningococcal meningitis and septicaemia. Many people are nasopharyngeal carriers of Neisseria meningitidis but few develop invasive disease. Factors associated with invasion include viral infection, dry dusty air, and passive smoking. Bacterial factors related to invasiveness in the nasopharynx include adhesion factors, IgA.

Pathophysiology Meningiti

Meningitis Lab Manual: Methods for Diagnosis CD

  1. Meningitis occurs when the membranes that cover the brain and spinal cord become inflamed. This is normally caused by infection but can also have non-infectious causes. Read on to learn more about.
  2. Immunity to N. gonorrhoeae is a topic that until recently has been hard to define, because there is currently no clearly established state of immunity to gonorrhea in humans, which are the only natural host for this infection. Furthermore, until recently, only one animal model of genital tract infection has been developed, known as the estradiol-treated female mouse model
  3. Meningitis is an infection of the membranes (meninges) surrounding the brain and spinal cord. Meningitis can be caused by a bacterial, fungal or viral infection. Meningitis can be acute, with a quick onset of symptoms, it can be chronic, lasting a month or more, or it can be mild or aseptic
  4. Neisseria gonorrhoeae is a highly adapted human pathogen that utilises multiple adhesins to interact with a variety of host cell receptors. Recently, substantial progress has been made in unravelling the signalling events induced by N. gonorrhoae that can lead to cytoskeletal reorganisation, invasion or phagocytic uptake, intraphagosomal accommodation, nuclear signalling, cytokine/chemokine.
  5. Kimmitt PT, Kirby A, Perera N, et al. Identification of Neisseria gonorrhoeae as the causative agent in a case of culture-negative dermatitis-arthritis syndrome using real-time PCR. J Travel Med.
  6. Understanding the 5 Types of Meningitis. Meningitis is an umbrella term for five types of the disease, each characterized by its underlying cause

Gonorrhea is a common sexually transmitted infection (STI), and it can pass on during any kind of sexual contact. When a doctor diagnoses the issue early, they can usually treat it effectively Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The most common symptoms are fever, headache, and neck stiffness. Other symptoms include confusion or altered consciousness, vomiting, and an inability to tolerate light or loud noises. Young children often exhibit only nonspecific symptoms, such as. Pathogenic bacteria utilise a number of mechanisms to cause disease in human hosts. Bacterial pathogens express a wide range of molecules that bind host cell targets to facilitate a variety of different host responses. The molecular strategies used by bacteria to interact with the host can be unique to specific pathogens or conserved across several different species Figure 1. Interaction of Neisseria meningitidis with endothelial cells.N. meningitidis adhere to brain microvascular endothelial cells through an interaction between type IV pili and an unknown adhesion receptor (Nassif et al. 1994).Following initial bacterial adhesion, type IV pili mediate the recruitment and the activation of the β2-adrenoceptor thus leading to the organization of a. Meningitis is a potentially life-threatening infection of the meninges, the tough layer of tissue that surrounds the brain and the spinal cord.If not treated, meningitis can lead to brain swelling and cause permanent disability, coma, and even death. Meningitis has various causes, including bacterial infection (the most serious cases), viral infection, fungal infection, reactions to.

Meningococcal meningitis - WH

Pathogenesis Natural habitat and reservoir • N.meningitidis is a part of the normal non-pathogenic flora in the nasopharynx, urinal canal and anal canal • It colonizes and infects only humans, and has never been isolated from other animals • 5% to 10 % of adults are asymptomatic carriers • Infection is by aspiration of infective. Neisseria meningitidis. 1. NEISSERIA MENINGITIDIS Dr. K V CHAKRADHAR Assistant professor Department of Microbiology NRIIMS. 2. Morphology • Capsulated Gram negative cocci in pairs (diplococci) • 0.5 - 1 µm in size • Kidney shaped, flat sides adjacent • Intracellular, usually • Non motile • Non spore forming. 3 Meningococcal meningitis is caused by the bacterium Neisseria meningitides. Each year in the United States about 2,600 people get this highly contagious disease. High-risk groups include infants under the age of 1 year, people with suppressed immune systems, travelers to foreign countries where the disease is endemic, and college students. Neisseria meningitidis, an exclusive pathogen of humans, remains the leading worldwide cause of meningitis and fatal sepsis, usually in otherwise healthy individuals.In recent years, significant advances have improved our understanding of the epidemiology and genetic basis of meningococcal disease and led to progress in the development of the next generation of meningococcal vaccines La persistencia de Neisseria meningitidis se debe al gran porcentaje de portadores (cerca de 500 millones de personas en el mundo, en nasofaringe) y a la dinámica de transmisión de la bacteria, la cual incluye varios factores de transmisibilidad como tabaquismo, infecciones virales previas, hacinamiento, entre otras

Introduction. The Gram-negative species Neisseria meningitidis (the meningococcus) belongs to the β-subgroup of proteobacteria. They are facultative commensals, and their only habitat are humans with no other known reservoirs. Meningococci colonize the nasopharynx of up to 35% of healthy individuals at any given time, and direct person-to-person spread of meningococci occurs by large droplet. Via complement-mediated lysis When bacteria, such as Neisseria meningitidis, invade the body, they are attacked by immune proteins called complement proteins. Complement proteins assist in bacterial killing via three pathways, the classical complement pathway, the alternative complement pathway or the lectin pathway

Meningitis CD

  1. An RNase III-independent mechanism was discovered in the type II-C CRISPR-Cas system of Neisseria meningitidis. Here, promoter sequences were identified to lie within each repeat and some were able to initiate transcription leading to intermediate crRNA species
  2. Variable expression of the Opc outer membrane protein in Neisseria meningitidis is caused by size variation of a promoter containing poly-cytidine. Mol. Microbiol. 13 , 207-21
  3. Neisseria meningitidis Listeria monocytogenes If no organism can be isolated with routine culture and sensitivity assays of cerebrospinal fluid (CSF), the condition is called aseptic meningitis , and the etiology is likely viral (e.g. Enterovirus, HIV and HSV )

Neisseria gonorrhoeae host adaptation and pathogenesis

Meningococcal disease is a serious and potentially life-threatening infection caused by the bacterium Neisseria meningitidis. N. meningitidis can be classified into 12 serogroups based on its capsular polysaccharide; serogroups A, B, C, W, X, and Y are the primary causes of meningococcal disease worldwide • Neisseria gonorrhoea (gonococos) y Neisseria meningitidis (meningococos) son patógenos para humanos y por lo general se encuentran en los PMN. • Algunas Neisserias son habitantes normales del aparáto respiratorio humano; y muy pocas veces causan enfermedad y se encuentran fuera de las celulas In this case, protection Schematic representation of a large-scale genomic study of Neisseria against clinical disease did appear to correlate with CTL meningitidis [10 ••,11 ••] with the aim of providing protein-based responses. A prime-boost strategy involving DNA vacci- vaccine candidate antigens Neisseria Meningitidis is a bacteria that is best known for its role in endemic bacterial meningitis.N. Meningitidis is described as a gram-negative diplococci. The fact that this bacteria is gram negative means that there is very little or no peptidoglycan in the cell wall

Pathophysiology of meningococcal meningitis and septicaemi

MORPHOLOGY OF NEISSERIA MENINGITIDIS (MENINGOCOCCUS). Shape - Neisseria meningitidis is an oval or spherical (coccus) shape bacterium with the adjacent side flattened.. Size - The size of Neisseria meningitidis is about 0.6 µm - 0.8 µm (micrometer).. Arrangement Of Cells - Neisseria meningitidis is arranged in pairs (diplococci), with the adjacent side flattened and they are usually. The most common organisms of bacterial meningitis in children and adults are Streptococcus pneumoniae and Neisseria meningitidis. Streptococcus pneumoniae is declining after the introduction of conjugated vaccines. Hemophilus influenzae, once very common in children, is now rare thanks to vaccination. Pathogenesis. The organisms that cause.

Gonorrhea symptoms in men usually include: Burning when you pee. Painful or swollen testicles. White, yellow, or green discharge from your penis. Most women don't have symptoms. If they do, they. Symptoms of meningitis, septicaemia and meningococcal disease include: a high temperature. cold hands and feet. vomiting. confusion. breathing quickly. muscle and joint pain. pale, mottled or blotchy skin. spots or a rash Bacteria. Bacteria are single celled microbes. The cell structure is simpler than that of other organisms as there is no nucleus or membrane bound organelles. Instead their control centre containing the genetic information is contained in a single loop of DNA. Some bacteria have an extra circle of genetic material called a plasmid Sun YH, Bakshi S, Chalmers R, Tang CM (2000) Functional genomics of Neisseria meningitidis pathogenesis. Nat Med 6: 1269-1273.YH SunS. BakshiR. ChalmersCM Tang2000Functional genomics of Neisseria meningitidis pathogenesis.Nat Med612691273 . View Article PubMed/NCBI Google Scholar 32

Meningitis is an infection of the protective membranes that surround the brain and spinal cord (meninges). It can affect anyone, but is most common in babies, young children, teenagers and young adults. Meningitis can be very serious if not treated quickly. It can cause life-threatening blood. Transformational exchanges in the dihydropteroate synthase gene of Neisseria meningitidis: a novel mechanism for acquisition of sulfonamide resistance. J. Bacteriol. 174, 6386-6393. doi: 10.1128/jb.174.20.6386-6393.199 Staphylococcus aureus (S. aureus) causes a broad range of infections. This variety is related to a number of virulence factors that allow it to adhere to surface, invade or avoid the immune system.

We describe a procedure by which a population of mutagenized N. meningitidis is enriched for mutants with specific growth phenotypes. These experiments used a simple defined medium (modified from that described in J Bacteriol 1962; 83: 470-474) in which meningococci grow well on a variety of carbon sources Summary. Meningitis is a serious infection of the meninges in the brain or spinal cord that is most commonly viral or bacterial in origin, although fungal, parasitic, and noninfectious causes are also possible. Enteroviruses and herpes simplex virus are the leading causes of viral meningitis, while Neisseria meningitidis and Streptococcus pneumoniae are the pathogens most commonly responsible. Meningitis is an inflammation of the thin membranes that cover the brain and the spinal cord. It is most often caused by a bacterial or viral infection that moves into the cerebral spinal fluid. A fungus or parasite may also cause meningitis. Meningitis caused by a virus is more common and usually less severe da Silva, R. A. G. et al. The role of apolipoprotein N-acyl transferase, Lnt, in the lipidation of factor H binding protein of Neisseria meningitidis strain MC58 and its potential as a drug target. Neisseria meningitidis is a human pathogen causing life-threatening diseases worldwide with high levels of mortality and morbidity. Vaccination remains an excellent strategy for preventing.

Most meningeal pathogens are transmitted through the respiratory route, including Neisseria meningitidis (meningococcus) and S pneumoniae (pneumococcus). Certain respiratory viruses are thought to enhance the entry of bacterial agents into the intravascular compartment, presumably by damaging mucosal defenses SUMMARY The only natural reservoir of Neisseria meningitidis is the human nasopharyngeal mucosa. Depending on age, climate, country, socioeconomic status, and other factors, approximately 10% of the human population harbors meningococci in the nose. However, invasive disease is relatively rare, as it occurs only when the following conditions are fulfilled: (i) contact with a virulent strain. Protein-protein interactions (PPIs) and multi-protein complexes perform central roles in the cellular systems of all living organisms. In humans, disruptions of the normal patterns of PPIs and protein complexes can be causative or indicative of a disease state. Recent developments in the biological applications of mass spectrometry (MS)-based proteomics have expanded the horizon for the.

Staphylococcus epidermidis from Neisseria meningitidis b. Staphylococcus aureus from Staphylococcus epidermidis c. Streptococcus pyogens from Staphylococcus aureus d. Streptococcus pyogens from Enterococcus faecalis; Answer Key for MCQ Microbiology: d (Ribosomes) d (Mycobacterium tuberculosis stains blue because it has a thick lipid layer Pathogenesis and symptoms: All serotypes of Salmonella enterica are pathogenic to humans and mammals, while serotypes of Salmonella bongori are typically found in birds and cold-blooded animals

Meningococcus is the common name of Neisseria meningitidis and causes meningitis (infections of the lining of the brain and spinal cord) and bloodstream infections (bacteremia or septicemia). The genus Neisseria is named after the German bacteriologist Albert Neisser, who discovered Neisseria gonorrhoeae , the pathogen that causes the human. Neisseria meningitidis, [1] generalmente denominada meningococo, es una bacteria gramnegativa que puede causar meningitis y otras formas de enfermedad meningocócica, por ejemplo meningococemia, un tipo de sepsis potencialmente mortal. Esta bacteria se conoce como coco porque es redonda y más específicamente como diplococo porque tiende a formar pares Meningococcemia is defined as dissemination of meningococci (Neisseria meningitidis) into the bloodstream (see the image below). Patients with acute infection can present clinically with (1) meningitis, (2) meningitis with meningococcemia, or (3) meningococcemia without obvious meningitis

Meningitis - Symptoms and causes - Mayo Clini

Chocolate Agar (CAP or CHOC) is a nonselective, enriched medium used for the isolation and identification of fastidious pathogens. Chocolate agar is prepared by heating blood agar, which in turn ruptures the red blood cell (RBC) and releases nutrients that aid in the growth of fastidious bacteria, most notably Haemophilus and Neisseria species. The name is derived from the fact that the lysis. Meningococcal disease caused by Neisseria meningitidis has a high case fatality rate. Of 12 distinct serogroups, A, B, C, W-135 (W) and Y cause the majority of infections. The meningococcal disease burden and epidemiology in India are not reliably known. Hence, we performed a narrative review with a systematically conducted search to summarize information on meningococcal disease burden and. The most common causes of non-neonatal bacterial meningitis are Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. All three of these bacterial pathogens are spread from person to person by respiratory secretions. Each can colonize and cross through the mucous membranes of the oropharynx and nasopharynx, and enter the. The likelihood of having a positive Gram stain result also depends on the specific bacterial pathogen causing meningitis [3, 10]: 90% of cases caused by Streptococcus pneumoniae, 86% of cases caused by Haemophilus influenzae, 75% of cases caused by Neisseria meningitidis, 50% of cases caused by gram-negative bacilli, and approximately one-third.

Aseptic and Bacterial Meningitis: Evaluation, Treatment

Abi R's story. October 2021 will mark 20 years since Abi contracted meningococcal septicaemia, leaving her with an acquired brain injury and painful mobility. Her mission now is to normalise mobility aids and inspire others to be proud of theirs too In order for a successful infection and creating a satisfactory environment inside the host, strains of uropathogenic Escherichia coli (UPEC) need some special features that are achieved by expressing particular genes, called virulence factors. Two of the most important surface virulence factors of UPEC are type 1 fimbriae and P fimbriae that are crucial for the colonization process inside the. Have you had enough chocolate in the last video? If not, our organism for the day deals with chocolate, too ;). Today we will be talking about Neisseria gono.. June 20, 2021. June 15, 2021 by Editors. Microbiology is the study of tiny organisms that affect the human body. The subject is essential for nursing students as it highlights the behaviors of microscopic organisms that can negatively impact the lives of human beings. While nursing majorly dwells

Video: Meningitis: Symptoms, Causes, Transmission, and Treatmen

Meningitis: Symptoms, Causes, Types, Treatment, Risks, & Mor

Thank you for joining Medscape. As a Medscape Member, you will receive communications by email to alert you to important information in your specialty and across medicine, including selected information from industry tailored to your area of clinical practice from our WebMD Professional service.WebMD Professional service Complement is the term used to describe a group of serum proteins that are critically important in our defense against infection. There are deficiencies of each of the individual components of complement. Patients with complement deficiencies encounter clinical problems that depend on the role of the specific complement protein in normal function

Vaccine Effective Against 91% of Bacteria Causing CommonMeningitis: Causes and Risk FactorsNeisseria meningitidis - microbewikiNeisseria kochii - Gonorrhea - STD Information from CDCNeisseria sicca - Gonorrhea - STD Information from CDC

Lewis LA and Dyer DW. 1995. Identification of an iron-regulated outer membrane protein of Neisseria meningitidis involved in the utilization of hemoglobin complexed to haptoglobin. J. Bacteriol. 177:1299-1306 NEISSERIA MENINGITIDIS Gram negative oval/spherical cocci 0.6 to 0.8 µm in size Arranged in pairs (adjacent sides flattened) Bean shaped Encapsulated Shape of Neisseria meningitidis Described and isolated by weichselbaum from spinal fluid of patient,1887 7 Neisseria meningitidis - slideshare . Only N. gonorrhoeae and N. meningitidis are regarded as pathogens Footnote 1, Footnote 2. 2) Neisseria species associated with animals include: N. canis, N. weaveri (dogs), N. denitrificans (guinea pigs), N. macacae (rhesus monkey), N. dentiae (cows), and N. iguanae (lizards). Footnote 1, Footnot